Saturday December 16, 2006



Q: One side effect you need to be aware of Daptomycin (Cubicin) ?

A: Daptomycin induced rhabdomyolysis and consequently acute renal failure.

Daptomycin is a bactericidal antibiotic against most Gram-positive organisms including methicillin-resistant Staph. aureus (MRSA) and vancomycin-resistant enterococci (VRE). Initially, it was reported that if given as once a day instead of divided dose it prevents clinical rhabdomyolysis but recent reports describe rhabdomyolysis even with once a day dose.

Close monitoring of CPK and symptoms of myopathy is recommended in all patients started on daptomycin.



Read case report and discussion: Rhabdomyolysis and acute renal failure in a patient treated with daptomycin (Journal of Antimicrobial Chemotherapy)



Further reading : Click to get article/abstract

Severe myopathy and possible hepatotoxicity related to daptomycin - Journal of Antimicrobial Chemotherapy 2005 55(4):599-600